CARPA – Complement Activation-Related Pseudo-Allergy

What is CARPA?

The Complement System is the name of a group of proteins which circulate in the blood and tissue fluids. They are activated by the presence of molecular components they don’t recognise. This can be bacteria or viruses, but also damaged human cells and drug components they have never encountered before.

The proteins become sequentially activated in an enzyme cascade which can trigger an inflammatory immune response. This is what the term Activation-Related refers to.

Pseudo-Allergy means that the reaction is not a genuine IgE allergy but can present itself as one. A genuine allergy means that the body reacts in the same or similar way every time it is exposed to a specific allergen and can be detected by an IgE blood test. A pseudo-allergic reaction can be a single incident that would not be repeated on a subsequent exposure to the same allergen and would not show any sensitisation in an IgE blood test.

If you want to read more on the topic and access all the additional resources check out my website at –

The majority of my posts are no longer on WordPress – follow me on  Facebook  or Twitter if you don’t want to miss my monthly round-ups or allergy card updates!


Published by Jemma D

I love to write about food allergies, asthma and eczema.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

Create your website with
Get started
%d bloggers like this: